Electrolyzed Hydrogen Water -Radiation Protection
Hydrogen as a New Class of Radioprotective Agent
It is well known that most of the ionizing radiation-induced damage is caused by hydroxyl radicals (·OH) follows radiolysis of H2O. Molecular hydrogen (H2) has antioxidant activities by selectively reducing ·OH and peroxynitrite(ONOO-). We firstly hypothesized and demonstrated the radioprotective effect of H2 in vitro and in vivo, which was also repeated on different experimental animal models by different departments. A randomized, placebo-controlled study showed that consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects. These encouraging results suggested that H2 represents a potentially novel preventative strategy for radiation-induced oxidative injuries. H2 is explosive. Therefore, administration of hydrogen-rich solution (physiological saline/pure water/other solutions saturated with H2) may be more practical in daily life and more suitable for daily consumption. This review focuses on major scientific and clinical advances of hydrogen-rich solution/H2 as a new class of radioprotective agent.
Although a remarkable progress about the application of hydrogen as a radioprotectant has been made in past 6 years, there were only a few clinical data. Ki-Mun Kang et al. performed a randomised, placebo-controlled study on 49 patients receiving radiotherapy for malignant liver tumour. Hydrogen-rich water was produced by metallic magnesium (Mg) [Mg + 2H 2 O = Mg (OH)2+ H2 ], and the final concentration of H2 reached to 0.55-0.65 mM. Results showed that daily consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential of these patients. Quality of life (QOL) scored during radiotherapy were improved in patients with hydrogen-rich water compared to those with placebo. This study did not find differences in tumor response to radiotherapy as application of hydrogen-rich water.